MOTS-c – Research Grade Peptide

MOTS-c for Laboratory Research

MOTS-c is a synthetic peptide based on a naturally occurring mitochondrial-derived peptide (MDP) encoded within mitochondrial DNA. It has attracted significant scientific interest for its role in mitochondrial biology, cellular metabolism, and energy regulation. As one of the first identified mitochondrial peptides with signaling functions beyond the mitochondria, MOTS-c has become an important research tool for investigating metabolic adaptation and cellular stress responses.

Pure Peptides supplies research-grade MOTS-c manufactured under strict quality standards for laboratory research applications.

---

Product Specifications

• Product Name: MOTS-c
• Other Names: Mitochondrial Open Reading Frame of the 12S rRNA-c
• Form: Sterile Lyophilized (Freeze-Dried) Peptide
• Appearance: White to Off-White Lyophilized Powder
• Purity: ≥98% (HPLC Verified)
• Grade: Research Grade
• Available Sizes: Multiple vial sizes
• Research Use Only – Not for Human or Veterinary Use

---

Research Overview

MOTS-c is widely studied in laboratory investigations involving:

• Mitochondrial biology
• Cellular energy metabolism
• Metabolic signaling pathways
• Exercise physiology research
• Cellular stress response
• Glucose metabolism
• Aging biology
• Skeletal muscle research

Published preclinical and clinical research continues to investigate the biological functions of MOTS-c. Findings are specific to individual experimental models and should not be interpreted as established clinical outcomes.

---

Mechanism Under Investigation

Current scientific research suggests that MOTS-c functions as a signaling peptide involved in communication between mitochondria and the cell nucleus.

Areas under active investigation include:

• Mitochondrial-to-nuclear signaling
• AMP-activated protein kinase (AMPK) pathways
• Cellular metabolic regulation
• Oxidative stress response
• Glucose utilization
• Mitochondrial adaptation
• Cellular homeostasis

The complete molecular mechanisms of MOTS-c continue to be investigated in laboratory settings.

---

Technical Data

Property	Specification
Molecular Class	Mitochondrial-Derived Peptide (MDP)
Appearance	White Lyophilized Powder
Form	Sterile Freeze-Dried Peptide
Purity	≥98%
Analytical Testing	HPLC & Mass Spectrometry
Solubility	Water Soluble
Recommended Solvent	Bacteriostatic Water
Storage (Lyophilized)	Below −18°C
Storage (Reconstituted)	2–8°C short-term or below −18°C long-term
Light Sensitivity	Protect from Light

---

Storage & Handling

For optimal peptide stability:

• Store unopened vials below −18°C in a dry environment.
• Allow both the peptide and solvent to reach room temperature before reconstitution.
• Reconstitute using bacteriostatic water under appropriate laboratory conditions.
• Store reconstituted solutions refrigerated for short-term laboratory use.
• Avoid repeated freeze-thaw cycles.
• Protect from prolonged exposure to light.

---

Quality Assurance

Every batch of MOTS-c undergoes rigorous quality control procedures, including:

• High-performance liquid chromatography (HPLC)
• Mass spectrometry identity verification
• Lot-specific documentation
• Batch traceability
• Temperature-controlled shipping

Certificates of Analysis (COAs) are available upon request.

---

Frequently Asked Questions

What is MOTS-c?

MOTS-c is a synthetic version of a naturally occurring mitochondrial-derived peptide used in laboratory research to investigate mitochondrial signaling and metabolic regulation.

What research areas commonly use MOTS-c?

Researchers study MOTS-c in investigations involving mitochondrial biology, metabolism, cellular signaling, exercise physiology, glucose metabolism, and healthy aging.

How should MOTS-c be stored?

Store lyophilized material below −18°C. After reconstitution, refrigerate for short-term laboratory use or freeze below −18°C for longer storage. Avoid repeated freeze-thaw cycles.

Is MOTS-c approved for human use?

No. MOTS-c supplied by Pure Peptides is intended exclusively for laboratory research and is not approved for human consumption, therapeutic use, diagnostic applications, or veterinary use.

---

Regulatory Disclaimer

MOTS-c is supplied strictly for laboratory research purposes. This product is not a drug, dietary supplement, cosmetic, or food product. It has not been evaluated by the U.S. Food and Drug Administration (FDA) and is not approved for therapeutic, diagnostic, or human use. Purchasers are responsible for complying with all applicable laws and regulations governing the handling and use of research materials.