Mazdutide – Research Grade Peptide

Mazdutide for Laboratory Research

Mazdutide is a synthetic peptide analogue derived from oxyntomodulin, a naturally occurring gut hormone with activity at both the glucagon-like peptide-1 (GLP-1) and glucagon receptors. Unlike many dual agonists developed from GLP-1-based scaffolds, Mazdutide retains the dual receptor characteristics of its natural precursor while incorporating structural modifications designed to improve stability and extend duration of action.

Mazdutide has become an important investigational peptide in metabolic research, with published preclinical and clinical studies examining receptor pharmacology, energy metabolism, hepatic lipid biology, and glucose regulation.

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Product Specifications

• Product Name: Mazdutide
• Other Names: IBI362, LY3305677
• Form: Sterile lyophilized (freeze-dried) peptide
• Appearance: White lyophilized powder
• Grade: Research Grade
• Available Sizes: Multiple vial sizes
• Research Use Only – Not for Human or Veterinary Use

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Research Overview

Mazdutide is commonly investigated in laboratory and clinical research involving:

• Dual GLP-1 and glucagon receptor pharmacology
• Metabolic pathway research
• Energy balance studies
• Hepatic lipid metabolism
• Comparative incretin biology
• Oxyntomodulin analogue research

Published studies have evaluated Mazdutide in both preclinical models and controlled clinical investigations. Observations reported in the literature are specific to those study conditions and should not be interpreted as evidence of clinical benefit outside approved research settings.

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Mechanism Under Investigation

Mazdutide is designed to activate both the GLP-1 receptor and the glucagon receptor, two Class B G-protein-coupled receptors involved in metabolic regulation.

Current areas of scientific investigation include:

• Dual receptor signaling
• Oxyntomodulin pharmacology
• Glucose-dependent metabolic pathways
• Hepatic lipid metabolism
• Energy expenditure mechanisms
• Peptide structure-function relationships

The precise balance between receptor activities and its physiological implications continue to be actively investigated.

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Technical Data

Property	Specification
Molecular Class	Oxyntomodulin Analogue
Pharmacological Class	Dual GLP-1 / Glucagon Receptor Agonist
Appearance	White Lyophilized Powder
Form	Sterile Freeze-Dried Peptide
Solubility	Water Soluble
Recommended Solvent	Bacteriostatic Water
Analytical Testing	HPLC & Mass Spectrometry
Storage (Lyophilized)	Below −18°C
Storage (Reconstituted)	2–8°C short-term or below −18°C long-term
Light Sensitivity	Protect from Light

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Storage & Handling

For maximum stability:

• Store unopened vials below −18°C in a dry environment.
• Allow both the peptide and solvent to reach room temperature before reconstitution.
• Reconstitute using bacteriostatic water under appropriate laboratory conditions.
• Protect reconstituted solutions from prolonged light exposure.
• Avoid repeated freeze-thaw cycles.

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Quality Assurance

Every batch undergoes rigorous quality control procedures including:

• High-performance liquid chromatography (HPLC)
• Mass spectrometry identity verification
• Batch traceability
• Lot-specific quality documentation
• Temperature-controlled shipping

Certificates of Analysis (COAs) are available upon request.

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Frequently Asked Questions

What is Mazdutide?

Mazdutide is an investigational synthetic peptide based on the naturally occurring hormone oxyntomodulin and is studied for its dual activity at GLP-1 and glucagon receptors.

What are IBI362 and LY3305677?

IBI362 and LY3305677 are development code names used during Mazdutide’s research and clinical development.

What areas of research use Mazdutide?

Researchers investigate Mazdutide in studies involving metabolic regulation, receptor pharmacology, hepatic lipid biology, incretin signaling, and peptide structure-function relationships.

How should Mazdutide be stored?

Store lyophilized material below −18°C. After reconstitution, refrigerate for short-term laboratory use or freeze below −18°C for longer storage while protecting the solution from light.

Is Mazdutide approved for human use?

No. Mazdutide supplied by Pure Peptides is intended exclusively for laboratory research and is not approved for human consumption, therapeutic use, diagnostic applications, or veterinary use.

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Regulatory Disclaimer

Mazdutide is supplied strictly for laboratory research purposes. This product is not a drug, dietary supplement, cosmetic, or food product. It has not been evaluated by the U.S. Food and Drug Administration (FDA) for safety or effectiveness and must not be used for therapeutic, diagnostic, or human applications. Purchasers are responsible for ensuring compliance with all applicable laws and regulations governing the handling and use of research materials.